The potential anti-obesity mechanisms include appetite regulation, lipid digestion/absorption intervention, fatty acid oxidation, regulation of lipogenesis and lipolysis . Recently, algae are considered to be a good source for anti-obesity agents. Spirulina is a algae that can be consumed by humans and other animals. This study showed that Spirulina supplementation significantly decreased obesity and lipid accumulation in the liver.
The increasing consumption of high-fat diets and “fast food” leads to more and more obesity,which has become a major public health concern in the world. Obesity was considered to be association with chronic health disorders such as hyperlipidemia, hypertension, cardiovascular diseases, non-alcoholic fatty liver, insulin resistance and osteoarthritis. Mankind has been fighting against obesity, however, the adverse side effects and rebound weight gain are major challenge for conventional drug therapies of obesity. There are continuing needs to develop safe and effective remedies to treat obesity.
The microalgae Spirulina could be a promising candidate for dietary supplementation that may help prevent obesity and non-alcoholic fatty liver disease.
The increasing prevalence of obesity has become a public health problem worldwide. Obesity increases the risk of developing a variety of pathological conditions, including fatty liver disease, type 2 diabetes, hypertension and cardiovascular disease.
Spirulina (Arthrospira platensis) is a microalgae rich in essential amino acids, polyunsaturated fatty acids (PUFAs), minerals, vitamins and carotenoids. In recent decades, several studies in humans and rodents have demonstrated the beneficial effects of Spirulina on various diseases, including the reduction of blood cholesterol, protection against certain cancers, suppression of oxidative stress, increase of the immune system and reduction of hyperlipidemia and obesity.
Spirulina contains about 5-10% of its dry weight lipids. One of the main fatty acids in microalgae is gamma-linolenic acid, known to be the functional lipophilic compound of spirulina along with carotenoids, tocopherols and sterols.
In order to better understand the health benefits of Spirulina and improve the commercial value of microalgae, researchers from the University of Hokkaido, Qilu University of Technology (China) and Shandong University (China) conducted a study to evaluate and compare the effects of Spirulina and fish oil (FO) on diet-induced obesity and liver lipid accumulation in mice.
« After 12 weeks of feeding, Spirulina 4% gamma-linolenic acid supplementation was effective in reducing total weight gain, total white fat and liver lipid levels in obese mice, » the researchers report.
They indicate that Spirulina’s anti-obesity effect may be partly due to the presence of other classes of bioactive compounds in microalgae, such as B-carotene and zeaxanthin.
« The results confirm for the first time that Spirulina can relieve diet-induced obesity and lipid accumulation in the liver, » the researchers concluded.
Source: Source : Anti-obesity effects of Spirulina platensis protein hydrolysate by modulating brain-liver axis in high-fat diet fed mice. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586325/